Abstract
Three platinum complexes with cis and trans configuration
cis-[Pt(TCEP)2Cl2], cis-[Pt(tmTCEP)2Cl2] and trans-
[Pt(TCEP)2Cl2], where TCEP is tris(2-carboxyethyl)phosphine,
have been synthesized and fully characterized by usual
techniques including single-crystal X-ray diffraction for
trans-[Pt(TCEP)2Cl2] and cis-[Pt(tmTCEP)2Cl2]. Here, we also
report on an esterification process of TCEP, which takes place
in the presence of alcohols, leading to a platinum complex
coordinated to an ester tmTCEP (2-methoxycarbonylethyl
phosphine) ligand. The stability in solution of the three
compounds and their interaction with biological models
such as DNA (pBR322 and calf thymus DNA) and proteins
(lysozyme and RNase) have also been studied.
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Royal Society
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Este artículo describe la síntesis y caracterización de tres compuestos de platino como agentes que contienen ligandos fosfina en su estructura, y el análisis de su estabilidad, interacción con moléculas biológicas y actividad en células tumorales.
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Marcelo Echeverri, Amparo Alvarez-Valdés, Francisco Navas, Josefina Perles, Isabel Sánchez-Pérez, A. G. Quiroga. Royal Society of Chemistry Open Access, 2018, 5, 171340.
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