Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

dc.contributor.authorCrespo, Maria
dc.contributor.authornikolic, ivana
dc.contributor.authormora, alfonso
dc.contributor.authorrodriguez, elena
dc.contributor.authorleiva-vega, luis
dc.contributor.authorpintor-chocano, aranzazu
dc.contributor.authorHorrillo, Daniel
dc.contributor.authorhernandez-cosido, lourdes
dc.contributor.authortorres, Jorge
dc.contributor.authorNovoa, Eva
dc.contributor.authorNogueiras, ruben
dc.contributor.authormedina-gomez, Gema
dc.contributor.authormarcos, miguel
dc.contributor.authorleiva, magdalena
dc.contributor.authorsabio, guadalupe
dc.date.accessioned2024-01-25T05:45:16Z
dc.date.available2024-01-25T05:45:16Z
dc.date.issued2023
dc.description.abstractObesity features excessive fat accumulation in several body tissues and induces a state of chronic low-grade inflammation that contributes to the development of diabetes, steatosis and insulin resistance. Recent research has shown that this chronic inflammation is crucially dependent on p38 pathway activity in macrophages, suggesting p38 inhibitio n as a possible treatment for obesity comorbidities Nevertheless, we report here that lack of p38 activation in myeloid cells worsens high fat diet-induced obesity, diabetes, and steatosis. Deficient p38 activation increases macrophage IL-12 production, leading to inhibition of hepatic FGF21 and reduction of thermogenesis in the brown fat. The implication of FGF21 in the phenotype was confirmed by its specific deletion in hepatocytes. We also found that IL-12 correlates with liver damage in human biopsies, indicating the translational potential of our results. Our findings suggest that myeloid p38 has a dual role in inflammation and that drugs targeting IL-12 might improve the homeostatic regulation of energy balance in response to metabolic stress.es
dc.identifier.doi10.1002/hep.32581es
dc.identifier.issn0270-9139
dc.identifier.urihttps://hdl.handle.net/10115/28870
dc.language.isoenges
dc.publisherWolters Kluwer Health, Inces
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectMetabolimses
dc.subjectP-38 quinasaes
dc.titleMyeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axises
dc.typeinfo:eu-repo/semantics/articlees

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