Expression of clec9a in the oral cancer microenvironment. A preliminary immunohistochemical pilot study
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2021-09-01
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Sociedad Española de Periodoncia y Osteointegración (SEPA).
Resumen
Background: The search for treatments to improve cancer survival has led to the emergence of immunotherapy
and the study of the tumour microenvironment existing in neoplasms. This preliminary study aims to understand
the clinical and pathological relationship of clec9a expression in oral cancer and to explore survival models for
future studies.
Material and methods: Immunohistochemical study that included 26 patients with a diagnosis of oral squamous
cell carcinoma (OSCC) in mobile tongue and floor of the mouth. Clinical and histopathological variables were
recorded, and the biomarkers clec9a for dendritic cells and CD8 and CD4 for lymphocytes were used.
Results: Clec9a was expressed in 58% of the sample. It was more common in cases with low lymphoplasmacytic
infiltration and in type 2 invasion patterns. It was significantly related to CD8 expression (p=0.055 and p=0.007).
No prognostic risks were evident in the survival models studied (overall survival, disease-specific survival, dis-
ease-free survival).
Conclusions: CLEC9A expression is present in the OSCC microenvironment and is mainly related to the presence
of CD8 lymphocytes. The relationship of its expression with survival prognosis in OSCC could not be confirmed;
however, this needs to be confirmed through future studies with larger sample size.
Descripción
Funding: The research has been partially funded through a predoctoral research grant awarded by the Colegio Oficial de Odontólogos de Madrid (Official College of Dentists of Madrid) (Madrid, Spain).
Citación
Peña-Cardelles JF, Pozo-Kreilinger JJ, Roncador G, Esteban-Hernández J, Cebrián-Carretero JL, Moro-Rodríguez JE. Expression of clec9a in the oral cancer microenvironment. A preliminary immunohistochemical pilot study. Med Oral Patol Oral Cir Bucal. 2021 Sep 1;26(5):e651-e660. doi: 10.4317/medoral.24659. PMID: 34415004; PMCID: PMC8412449.
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