Microwave-assisted conversion of carbonyl compounds into formylated secondary amines: new contribution to the Leuckart reaction mechanism in N-methylformamide

dc.contributor.authorBarba, Fructuoso
dc.contributor.authorRecio, Javier
dc.contributor.authorBatanero, Belen
dc.date.accessioned2024-02-05T08:42:15Z
dc.date.available2024-02-05T08:42:15Z
dc.date.issued2013-04-03
dc.description.abstractThe reductive amination of several carbonyl compounds (Leuckart reaction) has been performed using Nmethylformamide and microwave technology. Under these conditions, a new mechanism is proposed via the initial formation of an imine, followed by reduction to the amine by ‘in situ’ generated formic acid, and further formylation of the amine. Using this methodology, the formyl derivatives of several secondary amines were obtained in good to excellent yields.es
dc.identifier.citationTetrahedron Letters 54 (2013) 1835–1838es
dc.identifier.doi10.1016/j.tetlet.2013.01.097es
dc.identifier.issn0040-4039
dc.identifier.urihttps://hdl.handle.net/10115/29592
dc.language.isoenges
dc.publisherELSERVIERes
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectReductive aminationes
dc.subjectLeuckart reactiones
dc.subjectMicrowave technologyes
dc.subjectRedox processes
dc.subjectFormylation of amineses
dc.titleMicrowave-assisted conversion of carbonyl compounds into formylated secondary amines: new contribution to the Leuckart reaction mechanism in N-methylformamidees
dc.typeinfo:eu-repo/semantics/articlees

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