Microwave-assisted conversion of carbonyl compounds into formylated secondary amines: new contribution to the Leuckart reaction mechanism in N-methylformamide

dc.contributor.author	Barba, Fructuoso
dc.contributor.author	Recio, Javier
dc.contributor.author	Batanero, Belen
dc.date.accessioned	2024-02-05T08:42:15Z
dc.date.available	2024-02-05T08:42:15Z
dc.date.issued	2013-04-03
dc.description.abstract	The reductive amination of several carbonyl compounds (Leuckart reaction) has been performed using Nmethylformamide and microwave technology. Under these conditions, a new mechanism is proposed via the initial formation of an imine, followed by reduction to the amine by ‘in situ’ generated formic acid, and further formylation of the amine. Using this methodology, the formyl derivatives of several secondary amines were obtained in good to excellent yields.	es
dc.identifier.citation	Tetrahedron Letters 54 (2013) 1835–1838	es
dc.identifier.doi	10.1016/j.tetlet.2013.01.097	es
dc.identifier.issn	0040-4039
dc.identifier.uri	https://hdl.handle.net/10115/29592
dc.language.iso	eng	es
dc.publisher	ELSERVIER	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.accessRights	info:eu-repo/semantics/restrictedAccess	es
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Reductive amination	es
dc.subject	Leuckart reaction	es
dc.subject	Microwave technology	es
dc.subject	Redox process	es
dc.subject	Formylation of amines	es
dc.title	Microwave-assisted conversion of carbonyl compounds into formylated secondary amines: new contribution to the Leuckart reaction mechanism in N-methylformamide	es
dc.type	info:eu-repo/semantics/article	es

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