Chiral Monolithic Silica-Based HPLC Columns for Enantiomeric Separation and Determination: Functionalization of Chiral Selector and Recognition of Selector-Selectand Interaction

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dc.contributor.authorAsmari, Mufarreh
dc.contributor.authorWang, Xiaoyu
dc.contributor.authorCasado, Natalia
dc.contributor.authorPiponski, Marjan
dc.contributor.authorKovalenko, Sergiy
dc.contributor.authorLogoyda, Liliya
dc.contributor.authorHanafi, Rasha Sayed
dc.contributor.authorEl Deeb, Sami
dc.date.accessioned2024-01-30T10:39:51Z
dc.date.available2024-01-30T10:39:51Z
dc.date.issued2021-08-29
dc.descriptionThis research received no external funding.es
dc.description.abstractThis review draws attention to the use of chiral monolithic silica HPLC columns for the enantiomeric separation and determination of chiral compounds. Properties and advantages of monolithic silica HPLC columns are also highlighted in comparison to conventional particle-packed, fused-core, and sub-2- m HPLC columns. Nano-LC capillary monolithic silica columns as well as polymeric-based and hybrid-based monolithic columns are also demonstrated to show good enantioresolution abilities. Methods for introducing the chiral selector into the monolithic silica column in the form of mobile phase additive, by encapsulation and surface coating, or by covalent functionalization are described. The application of molecular modeling methods to elucidate the selector–selectand interaction is discussed. An application for enantiomeric impurity determination is also considered.es
dc.identifier.citationAsmari, M.;Wang, X.; Casado, N.; Piponski, M.; Kovalenko, S.; Logoyda, L.; Hanafi, R.S.; El Deeb, S. Chiral Monolithic Silica-Based HPLC Columns for Enantiomeric Separation and Determination: Functionalization of Chiral Selector and Recognition of Selector-Selectand Interaction. Molecules 2021, 26, 5241es
dc.identifier.doi10.3390/ molecules26175241es
dc.identifier.issn1420-3049
dc.identifier.urihttps://hdl.handle.net/10115/29210
dc.language.isoenges
dc.publisherMDPIes
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectchiral chromatographyes
dc.subjectmonolithic silicaes
dc.subjectchiral selectores
dc.subjectimmobilizationes
dc.subjectenantiomerses
dc.subjectenantiomeric separationes
dc.subjectenantiomeric impurityes
dc.subjectmolecular modelinges
dc.titleChiral Monolithic Silica-Based HPLC Columns for Enantiomeric Separation and Determination: Functionalization of Chiral Selector and Recognition of Selector-Selectand Interactiones
dc.typeinfo:eu-repo/semantics/reviewes

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