Miniaturized and modified QuEChERS method with mesostructured silica as clean-up sorbent for pyrrolizidine alkaloids determination in aromatic herbs

dc.contributor.authorIzcara, Sergio
dc.contributor.authorCasado, Natalia
dc.contributor.authorMorante-Zarcero, Sonia
dc.contributor.authorPérez-Quintanilla, Damián
dc.contributor.authorSierra, Isabel
dc.date.accessioned2022-06-08T07:12:56Z
dc.date.available2022-06-08T07:12:56Z
dc.date.issued2022-06
dc.description.abstractThis work proposes the miniaturization and modification of the QuEChERS strategy using different large pore mesostructured silicas, non-modified and modified with amino groups (NH2), as dispersive clean-up sorbents for multi-component extraction of 21 pyrrolizidine alkaloids from different aromatic herbs, combined with ultra-high performance liquid chromatography coupled to tandem mass spectrometry analysis. The procedure was miniaturized by reducing the amounts of sample (0.2 g), solvents (2 mL), clean-up sorbents (25 mg sorbent + 150 mg MgSO4) and partitioning salts (0.65 g) employed. Best results were achieved using mesostructured silicas (LP-MS-NH2) than conventional PSA. The method was validated (overall recoveries 73–105%) and applied to the analysis of 17 samples. All the samples were contaminated with PAs (average concentration 262 µg/Kg). Thyme and basil samples were the most contaminated, whereas rosemary was the least. Lasiocarpine, senecivernine N-oxide and europine N-oxide were the main PAs that contributed to their contamination.es
dc.identifier.citationSergio Izcara, Natalia Casado, Sonia Morante-Zarcero, Damián Pérez-Quintanilla, Isabel Sierra, Miniaturized and modified QuEChERS method with mesostructured silica as clean-up sorbent for pyrrolizidine alkaloids determination in aromatic herbs, Food Chemistry, Volume 380, 2022, 132189, ISSN 0308-8146, https://doi.org/10.1016/j.foodchem.2022.132189es
dc.identifier.doi10.1016/j.foodchem.2022.132189es
dc.identifier.issn0308-8146
dc.identifier.urihttp://hdl.handle.net/10115/19469
dc.language.isoenges
dc.publisherElsevieres
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPyrrolizidine alkaloidses
dc.subjectAromatic herbses
dc.subjectMesostructured silicases
dc.subjectµ-QuEChERSes
dc.subjectUHPLC-MS/MSes
dc.subjectFood safetyes
dc.titleMiniaturized and modified QuEChERS method with mesostructured silica as clean-up sorbent for pyrrolizidine alkaloids determination in aromatic herbses
dc.typeinfo:eu-repo/semantics/articlees

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