Biomarkers for SARS-CoV-2 infection. A narrative review

dc.contributor.authorSnopkowska Lesniak, Sara Weronika
dc.contributor.authorMaschio, Diego
dc.contributor.authorHenriquez-Camacho, Cesar
dc.contributor.authorMoreno Cuerda, Victor
dc.date.accessioned2025-07-21T06:21:49Z
dc.date.available2025-07-21T06:21:49Z
dc.date.issued2025-03-26
dc.description.abstractCOVID-19 is an infectious disease caused by SARS-CoV-2 with devastating effects on health-care systems. The magnitude of the problem has moved physicians and investigators to identify strategies to detect patients at a high risk of severe disease. The aim of this study was to identify the most relevant biomarkers in the published literature and their correlation with clinical outcomes. To this end, we performed a revision of studies that investigated laboratory abnormalities in patients with COVID-19, comparing non-severe and severe patients. Blood biomarkers were classified into five main categories: hematological, coagulation related to the liver or kidney, and inflammatory. From our analysis, the most relevant biomarkers associated with severe infection for each category were increased levels of leukocytes, neutrophils, and neutrophil-to-lymphocyte ratio; decreased platelet count; and high levels of aspartate transaminase, alanine transaminase, creatine kinase, troponin, creatinine, and blood urea nitrogen, C-reactive protein, ferritin, and IL-6. Moreover, lactate dehydrogenase and D-dimer levels were independent risk factors for death.
dc.identifier.citationSnopkowska Lesniak SW, Maschio D, Henriquez-Camacho C, Moreno Cuerda V. Biomarkers for SARS-CoV-2 infection. A narrative review. Front Med (Lausanne). 2025 Mar 26;12:1563998
dc.identifier.doi10.3389/fmed.2025.1563998
dc.identifier.other40206469
dc.identifier.urihttps://hdl.handle.net/10115/93717
dc.language.isoen
dc.publisherFrontiers
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCOVID-19
dc.subjectSARS CoV-2
dc.subjectbiomarkers
dc.subjectmortality
dc.subjectprognosis
dc.titleBiomarkers for SARS-CoV-2 infection. A narrative review
dc.typeArticle

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