Effect of Ca2+ Agonist Bay K 8644 in human placental arteries
| dc.contributor.author | Barrús, MT | |
| dc.contributor.author | Reviriego, J | |
| dc.contributor.author | Marín, J | |
| dc.date.accessioned | 2024-07-08T11:50:43Z | |
| dc.date.available | 2024-07-08T11:50:43Z | |
| dc.date.issued | 1995-09 | |
| dc.description.abstract | 1. Bay K 8644 (0.1 μM) induced weak contractions in human placental artery segments that were increased in the presence of 7.5 mM K+. K+ and serotonin (5-HT) induced contractions that were enhanced by preincubation of segments with Bay K 8644. These enhancements were reduced by nifedipine (0.1 μM) and diltiazem (1 μM). 2. Bay K 8644 induced a 45Ca2+ uptake increase which was potentiated by depolarization with K+ (less than 30 mM) and antagonized by nifedipine. K+ (15 and 30 mM) and 5-HT (1 μM) induced 45Ca2+ uptake that was enhanced by Bay K 8644. 3. These results suggest that Bay K 8644: (1) is unable to activate the quiescent potential-operated Ca2+ channels (POCs) of these arteries, and (2) activates receptor (5-HT)-operated Ca2+ channels or facilitates Ca2+ influx through POCs activated by 5-HT. | es |
| dc.identifier.citation | M.T. Barrús, J. Reviriego, J. Marin, Effect of Ca2+ Agonist Bay K 8644 in human placental arteries, General Pharmacology: The Vascular System, Volume 26, Issue 5, 1995, Pages 989-996, ISSN 0306-3623, https://doi.org/10.1016/0306-3623(94)00289-Y. | es |
| dc.identifier.doi | 10.1016/0306-3623(94)00289-Y | es |
| dc.identifier.issn | 0306-3623 | |
| dc.identifier.uri | https://hdl.handle.net/10115/37111 | |
| dc.language.iso | eng | es |
| dc.publisher | Elsevier | es |
| dc.rights.accessRights | info:eu-repo/semantics/closedAccess | es |
| dc.subject | Human placental arteriesBay K 8644nifedipinediltiazemcalcium channels | es |
| dc.title | Effect of Ca2+ Agonist Bay K 8644 in human placental arteries | es |
| dc.type | info:eu-repo/semantics/article | es |
Archivos
Bloque original
1 - 1 de 1
No hay miniatura disponible
- Nombre:
- 1995 GenPharmacol 26 5 989.pdf
- Tamaño:
- 681.91 KB
- Formato:
- Adobe Portable Document Format
- Descripción: