Myeloid GRK2 Regulates Obesity-Induced Endothelial Dysfunction by Modulating Inflammatory Responses in Perivascular Adipose Tissue
González-Amor, María; Vila-Bedmar, Rocio; Rodrigues-Díez, Raquel; Moreno-Carriles, Rosa; C. Arcones, Alba; Cruces-Sande, Marta; Salaices, Mercedes; Mayor Jr, Federico; Briones, Ana M.; Murga, Cristina
Date:
2020-10-04
Abstract
Perivascular adipose tissue (PVAT) is increasingly being regarded as an important endocrine organ that directly impacts vessel function, structure, and contractility in obesity-associated diseases. We uncover here a role for myeloid G protein-coupled receptor kinase 2 (GRK2) in the modulation of PVAT-dependent vasodilation responses.
Description
In this work we describe a potential role for GRK2 in myeloid cells in orchestrating the responses that promote both inflammation and excessive ROS production by NADPH oxidase in PVAT to decrease endothelium-dependent vasodilation.
Collections
- Artículos de Revista [3670]