Myeloid GRK2 Regulates Obesity-Induced Endothelial Dysfunction by Modulating Inflammatory Responses in Perivascular Adipose Tissue

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dc.contributor.authorGonzález-Amor, María
dc.contributor.authorVila-Bedmar, Rocio
dc.contributor.authorRodrigues-Díez, Raquel
dc.contributor.authorMoreno-Carriles, Rosa
dc.contributor.authorC. Arcones, Alba
dc.contributor.authorCruces-Sande, Marta
dc.contributor.authorSalaices, Mercedes
dc.contributor.authorMayor Jr, Federico
dc.contributor.authorBriones, Ana M.
dc.contributor.authorMurga, Cristina
dc.date.accessioned2023-12-22T08:32:48Z
dc.date.available2023-12-22T08:32:48Z
dc.date.issued2020-10-04
dc.descriptionIn this work we describe a potential role for GRK2 in myeloid cells in orchestrating the responses that promote both inflammation and excessive ROS production by NADPH oxidase in PVAT to decrease endothelium-dependent vasodilation.es
dc.description.abstractPerivascular adipose tissue (PVAT) is increasingly being regarded as an important endocrine organ that directly impacts vessel function, structure, and contractility in obesity-associated diseases. We uncover here a role for myeloid G protein-coupled receptor kinase 2 (GRK2) in the modulation of PVAT-dependent vasodilation responses.es
dc.identifier.citationGonzález-Amor, M.; Vila-Bedmar, R.; Rodrigues-Díez, R.; Moreno-Carriles, R.; Arcones, A.C.; Cruces-Sande, M.; Salaices, M.; Mayor, F., Jr.; Briones, A.M.; Murga, C. Myeloid GRK2 Regulates Obesity-Induced Endothelial Dysfunction by Modulating Inflammatory Responses in Perivascular Adipose Tissue. Antioxidants 2020, 9, 953.es
dc.identifier.doi10.3390/antiox9100953es
dc.identifier.issn2076-3921
dc.identifier.urihttps://hdl.handle.net/10115/27716
dc.language.isoenges
dc.publisherMDPIes
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectperivascular adipose tissue (PVAT)es
dc.subjectG protein-coupled receptor kinase 2 (GRK2)es
dc.subjecttumor necrosis factor-α (TNFα)es
dc.subjectNADPH oxidase (Nox)es
dc.subjectendothelial dysfunctiones
dc.titleMyeloid GRK2 Regulates Obesity-Induced Endothelial Dysfunction by Modulating Inflammatory Responses in Perivascular Adipose Tissuees
dc.typeinfo:eu-repo/semantics/articlees

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