Myeloid GRK2 Regulates Obesity-Induced Endothelial Dysfunction by Modulating Inflammatory Responses in Perivascular Adipose Tissue

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antioxidants-09-00953 (1).pdf (2.67 MB)

Fecha

2020-10-04

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MDPI

URI

https://hdl.handle.net/10115/27716

DOI

https://doi.org/10.3390/antiox9100953

Resumen

Perivascular adipose tissue (PVAT) is increasingly being regarded as an important endocrine organ that directly impacts vessel function, structure, and contractility in obesity-associated diseases. We uncover here a role for myeloid G protein-coupled receptor kinase 2 (GRK2) in the modulation of PVAT-dependent vasodilation responses.

Descripción

In this work we describe a potential role for GRK2 in myeloid cells in orchestrating the responses that promote both inflammation and excessive ROS production by NADPH oxidase in PVAT to decrease endothelium-dependent vasodilation.

Palabras clave

perivascular adipose tissue (PVAT) , G protein-coupled receptor kinase 2 (GRK2) , tumor necrosis factor-α (TNFα) , NADPH oxidase (Nox) , endothelial dysfunction

Citación

González-Amor, M.; Vila-Bedmar, R.; Rodrigues-Díez, R.; Moreno-Carriles, R.; Arcones, A.C.; Cruces-Sande, M.; Salaices, M.; Mayor, F., Jr.; Briones, A.M.; Murga, C. Myeloid GRK2 Regulates Obesity-Induced Endothelial Dysfunction by Modulating Inflammatory Responses in Perivascular Adipose Tissue. Antioxidants 2020, 9, 953.

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