Myeloid GRK2 Regulates Obesity-Induced Endothelial Dysfunction by Modulating Inflammatory Responses in Perivascular Adipose Tissue

González-Amor, María; Vila-Bedmar, Rocio; Rodrigues-Díez, Raquel; Moreno-Carriles, Rosa; C. Arcones, Alba; Cruces-Sande, Marta; Salaices, Mercedes; Mayor Jr, Federico; Briones, Ana M.; Murga, Cristina

doi:10.3390/antiox9100953

dc.contributor.author	González-Amor, María
dc.contributor.author	Vila-Bedmar, Rocio
dc.contributor.author	Rodrigues-Díez, Raquel
dc.contributor.author	Moreno-Carriles, Rosa
dc.contributor.author	C. Arcones, Alba
dc.contributor.author	Cruces-Sande, Marta
dc.contributor.author	Salaices, Mercedes
dc.contributor.author	Mayor Jr, Federico
dc.contributor.author	Briones, Ana M.
dc.contributor.author	Murga, Cristina
dc.date.accessioned	2023-12-22T08:32:48Z
dc.date.available	2023-12-22T08:32:48Z
dc.date.issued	2020-10-04
dc.identifier.citation	González-Amor, M.; Vila-Bedmar, R.; Rodrigues-Díez, R.; Moreno-Carriles, R.; Arcones, A.C.; Cruces-Sande, M.; Salaices, M.; Mayor, F., Jr.; Briones, A.M.; Murga, C. Myeloid GRK2 Regulates Obesity-Induced Endothelial Dysfunction by Modulating Inflammatory Responses in Perivascular Adipose Tissue. Antioxidants 2020, 9, 953.	es
dc.identifier.issn	2076-3921
dc.identifier.uri	https://hdl.handle.net/10115/27716
dc.description	In this work we describe a potential role for GRK2 in myeloid cells in orchestrating the responses that promote both inflammation and excessive ROS production by NADPH oxidase in PVAT to decrease endothelium-dependent vasodilation.	es
dc.description.abstract	Perivascular adipose tissue (PVAT) is increasingly being regarded as an important endocrine organ that directly impacts vessel function, structure, and contractility in obesity-associated diseases. We uncover here a role for myeloid G protein-coupled receptor kinase 2 (GRK2) in the modulation of PVAT-dependent vasodilation responses.	es
dc.language.iso	eng	es
dc.publisher	MDPI	es
dc.rights	Atribución 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	perivascular adipose tissue (PVAT)	es
dc.subject	G protein-coupled receptor kinase 2 (GRK2)	es
dc.subject	tumor necrosis factor-α (TNFα)	es
dc.subject	NADPH oxidase (Nox)	es
dc.subject	endothelial dysfunction	es
dc.title	Myeloid GRK2 Regulates Obesity-Induced Endothelial Dysfunction by Modulating Inflammatory Responses in Perivascular Adipose Tissue	es
dc.type	info:eu-repo/semantics/article	es
dc.identifier.doi	10.3390/antiox9100953	es
dc.rights.accessRights	info:eu-repo/semantics/openAccess	es

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