dc.contributor.author | Peña-Cardelles, Juan Francisco | |
dc.contributor.author | Pozo-Kreilinger, José Juan | |
dc.contributor.author | Roncador, Giovanna | |
dc.contributor.author | Esteban-Hernández, Jesús | |
dc.contributor.author | Moro-Rodríguez, José Ernesto | |
dc.contributor.author | Sastre-Perona, Ana | |
dc.contributor.author | Castelo-Fernández, Beatriz | |
dc.contributor.author | Cebrián-Carretero, José Luis | |
dc.date.accessioned | 2023-12-22T11:34:02Z | |
dc.date.available | 2023-12-22T11:34:02Z | |
dc.date.issued | 2022-03-19 | |
dc.identifier.citation | Peña-Cardelles, J.F.; Pozo-Kreilinger, J.J.; Roncador, G.; Esteban-Hernández, J.; Moro-Rodríguez, J.E.; Sastre-Perona, A.; Castelo-Fernández, B.; Cebrián-Carretero, J.L. Prognosis Value of Immunoregulatory Molecules in Oral Cancer Microenvironment: An Immunohistochemical Study. Biomedicines 2022, 10, 710. https://doi.org/10.3390/biomedicines10030710 | es |
dc.identifier.issn | 2227-9059 | |
dc.identifier.uri | https://hdl.handle.net/10115/27771 | |
dc.description | Funding: This research was funded by the Fundación para la investigación Biomédica Hospital
Universitario La Paz with the project number: EC_5474. The research has been partially funded
through a predoctoral research grant awarded by the Official College of Dentists of Madrid (Madrid,
Spain) with not project number associated. | es |
dc.description.abstract | Objectives: To evaluate the relationship of the immune-checkpoint PD-1/PD-L1 with
the clinical evolution of OSCC; to assess survival in OSCC based on the characteristics of TME
and histologic risk score; to evaluate the clinical and histopathological relationship of OSCC with
immunological TME. Material and Methods: A retrospective study was carried out on 65 samples
from patients with OSCC on the floor of the mouth or tongue. Clinicopathological variables and
the expression of the biomarkers PD-1, PD-L1, FoxP3, CD4, CD8, CSF1R, and p16 were recorded.
The relationship of the clinical and histological variables with the expression of the biomarkers and
survival was studied. Results: The univariate and multivariate analysis indicated that positive PD-1
expression was an independent protective factor for survival (overall, disease-free, disease-specific
survival) and that high PD-L1 also improved survival. Poorly differentiated histological grades and
metastasis were associated with a worse prognosis. Conclusions: PD-1 is a protective survival factor
that is maintained independently of PD-L1 expression. High values of PD-L1 expression also improve
survival. Higher expression of PD-1 is observed in smaller tumors, and higher expression of PD-L1
is more likely in women. No relationship between the tumor microenvironment and histologic risk
score was found to influence the survival patterns studied in the OSCC. There is no evidence of a
relationship between the histopathological features and the studied markers, although the positive
PD-1 and PD-L1 cases have a lower risk of a high WPOI score, and positive PD-1 expression was
associated with a lower DOI. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | oral cancer; microenvironment; risk score; PD-1; PD-L1 | es |
dc.title | Prognosis Value of Immunoregulatory Molecules in Oral Cancer Microenvironment: An Immunohistochemical Study | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.3390/ biomedicines10030710 | es |
dc.rights.accessRights | info:eu-repo/semantics/embargoedAccess | es |