Mesostructured Silicas as Cation-Exchange Sorbents in Packed or Dispersive Solid Phase Extraction for the Determination of Tropane Alkaloids in Culinary Aromatics Herbs by HPLC-MS/MS
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2022
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MDPI
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In this work, Hexagonal Mesoporous Silica (HMS) and Santa Barbara Amorphous-15
(SBA-15) mesostructured silicas were synthesized and functionalized with sulfonic acid groups.
The materials (HMS-SO3
�� and SBA-15-SO3
��) were evaluated as strong cation exchange sorbents
for sample extract clean-up, by solid phase extraction (SPE) and dispersive solid phase extraction,
to determine atropine (At) and scopolamine (Sc) in commercial culinary aromatic herbs. Under
optimized conditions, 0.25 g of sample was subject to solid–liquid extraction with acidified water
(pH 1.0), and good recovery percentages were achieved for At and Sc using 75 mg of HMS-SO3
�� in
SPE as the clean-up stage, prior to their determination by HPLC-MS/MS. The proposed method was
validated in a thyme sample showing recoveries in the range of 70–92%, good linearity (R2 > 0.999),
adequate precision (RSD 14%) and low limits (MDL 0.8–2.2 g/kg and MQL 2.6–7.2 g/kg for both
analytes). Sixteen aromatic herbs samples (dried thyme, basil and coriander leaves) were analysed
and At was found in fourteen samples over an interval of <5–42 g/kg, whereas Sc was found in
three of the sixteen samples studied (between <5–34 g/kg). The amount of At and Sc found in
some analysed samples confirms the importance of setting maximum levels of At and Sc in culinary
aromatic herbs.
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González-Gómez, L.; Gañán, J.; Morante-Zarcero, S.; Pérez-Quintanilla, D.; Sierra, I. Mesostructured Silicas as Cation-Exchange Sorbents in Packed or Dispersive Solid Phase Extraction for the Determination of Tropane Alkaloids in Culinary Aromatics Herbs by HPLC-MS/MS. Toxins 2022, 14, 218. https://doi.org/10.3390/toxins14030218
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